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The stories of people who suffer from rare and mysterious medical conditions. Some need surgery so complex that the odds of survival are slim.
At over 700-lbs, Jacky has barely had a chance to live. Now she is determined to discover the world anew, but ?rst she's got 500-lbs to lose.
The Johnstons say goodbye to their Finnish exchange student, Joose. Then, Elizabeth drops a bomb on her parents about her future plans with Brice.
Buddy follows his Aunt Nina's recipes to serve stuffed mussels, sauted escarole and a ricotta cheesecake with a Strega twist - but will she be impressed?
A son and daughter are brutally honest when they help their mum find a wedding dress. Plus, Al and Jo try to fix a family rift between bride Emma and her mum.
Despite losing eight stone, Amy still has seriously low self-esteem. Plus, blogger Laura has amazing confidence but very high expectations for her dream dress.
The crew mark their 100th anniversary with a memory lane cake and party. Plus, Buddy makes a special announcement about the future.
Buddy and four aspiring little bakers bake a "Make-A-Wish" cake. Buddy also plans to wow with a special hot air balloon cake.
Inspired by legendary Hoboken native, Frank Sinatra, Buddy prepares clams possillipo and a sweet lemon pasticiotti - and he's cooking them his way.
Jay's cheating makes Ashley hit the brakes, while Andrei fights for boundaries. And, life is hell for Colt and Larissa while they wait for her trial.
Nicole has a big surprise for Azan. Meanwhile, Larissa's behaviour drives Colt's mother over the edge and Elizabeth and Andrei get big news about their baby.
The team are surrounded by temptation when they are asked to make a cake for Dylan's candy bar and the sisters debate hiring an assistant for Buddy.
Buddy and his daughter Sophia make some of their favourite pizzas, like Margarita, Prosciutto and Arugula, Four Cheese and Sophia's Sweet Pizza.
Alec and Hilaria Baldwin return home after the trial to their kids and try to discover a new normal, and Alec agrees to go to therapy.
Jen makes a final decision about living off the grid with Charlie. After a blowout fight, Josh and Angela hash out the future of their relationship.
Stacey reveals a secret. Georgi attempts to lift his spirits in an unusual way, and Stacey and Florian get news that alters their future.
The family get creative as they help Winter get over her relationship with Jah. Plus, Chantel heads to the Dominican Republic to support Pedro.
The girls' trip to the Dominican Republic begins and Chantel and Karen try to cheer Winter up. Pedro wants Nicole's help in finding out answers about their dad.
Buddy reveals his popular pepper and prosciutto, and chicken and pesto Panini recipes. Plus, Aunt Frannie explains how make a perfect Manhattan clam chowder.
Buddy attempts his most difficult cake build to date, crafting giant cake houses to feed 4000 employees at Century 21's 40th anniversary.
Buddy surprises Anthony with a life size DJ set cake, complete with moving turntables and delivers a cake to a medevac unit by helicopter!
Alec and Hilaria try to move forward and focus on the kids. They attend a therapy but have different opinions about the next steps in their life.
After a big fight with Jah, Winter reveals things about her relationship with her family. Megan, River's girlfriend, meets Chantel and Karen, will they get along?
Life after the 90 days continues. As the couples look back at their journey on a K1 visa, the newlyweds realise that their lives have not become easier.
Amy wears a mask of makeup to hide the angry red blotches on her face. Dr Emma races to remove a tricky lipoma before the anaesthetic wears off.
The uplifting and inspirational stories of unique individuals around the world living with rare medical conditions, who are determined to live their best lives.
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